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Edition of Sunday, June 14, 2026

3 stories

Runner Describes Stable Angina Symptoms and Warns of Ignoring Chest Discomfort

Runner Describes Stable Angina Symptoms and Warns of Ignoring Chest Discomfort

Karthik describes experiencing exertion-related chest discomfort that he initially ignored, later identified as stable angina linked to undetected cholesterol problems, and urges readers not to dismiss such symptoms, citing a linked news story about a man who waited too long.

Original post · 2 min read
Please, please read this news thoroughly, for your own sake. I experienced chest discomfort only when I started to run at higher speeds, and it subsided when I just walked or was at rest. That's called 'stable angina' (or stress angina). Unhealthy cholesterol levels, high(er) blood pressure, diabetes are some of the causes for this - in my case, it was unhealthy cholesterol levels, long undetected, while my blood pressure, conversely, continues to be on the lower side because of my running... which my doctor confirmed as healthy since I wasn't experiencing associated fatigue. And I'm prediabetic too, as I discovered during the blood tests for my procedure.

Rana seems to have carried his 'chest discomfort' for 3 days, after which it was too late for any intervention. This is a thin line for most people because it is very easy to mistake a 'discomfort' for stomach acidity, physical symptoms like muscle strain, or even 'heartburn' (which is quite literal!). In a way, I obsess over my daily run more so for this - to include a reasonably stress-inducing activity every day (since there is none) to see if I feel completely alright with it. This helped me identify that I did experience something unusual and it needed medical intervention. And since I felt normal if I stopped the source of stress (running at a faster speed), I ignored it for about a week. But since it persisted exactly only when I stressed, I realized that I was going through something predictably unusual and that needed a check. This 'discomfort' was not a pain at all, ironically. It felt, at best, as a steady tingling sensation on my shoulders and neck - nothing close to my heart! All the more reason to ignore it. But it occurred every single time I stressed myself by increasing the speed of my run, and subsided if I just walked at a slower pace.

Related reading - Two blocks and a second chance tinyurl.com/2stents
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AI6/10

Analyst Argues Hardware-Algorithm Codesign Will Decide AI Hardware Winners

Bubble Boi argues that new accelerators offer inference features with no GPU or TPU equivalent, making hardware-algorithm codesign the decisive competitive frontier, and quotes Gavin Baker on diverging scale-up architectures eroding model portability across chips.

Original post · 1 min read
It’s only going to get worse.

I know of several features that new accelerators are adding that have no analogous operation on GPU, TPU, etc. most of these “special tricks” are on the inference domain and not only lower the TCO but also increase the model quality & capabilities.

Hardware-algo codesign is the last frontier left and it’s going to be the area that picks the winner in the end.
Gavin Baker @GavinSBaker
Much of Dwarkesh's argument hinges on this statment which *was* accurate but will be increasingly inaccurate on a go forward basis imo: 
 
“American labs port across accelerators constantly. Anthropic's models are run on GPUs, they're run on Trainium, they're run on TPUs. There are so many things you can do, from distilling to a model that's well fit for your chips.”
 
As system level architectures diverge (torus vs. switched scale-up topologies, memory hierarchies, networking primitives), true portability is eroding. The Mi300 and Mi325 had roughly the same scale-up domain size as Hopper whil…
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AI6/10

Google DeepMind Paper From AGI to ASI Includes Instructions for AI Agents

Google DeepMind Paper From AGI to ASI Includes Instructions for AI Agents▶

Dan McAteer highlights a Google DeepMind paper co-authored by cofounder Shane Legg, titled From AGI to ASI, which includes instructions letting an AI agent such as GPT-5.5 in Codex read and explain it alongside the user.

Original post · 1 min read
Okay, this is seriously cool.

A team from @GoogleDeepMind, including DeepMind Cofounder Shane Legg, published a paper "From AGI to ASI".

In the paper, they include instructions for an AI agent to read along with you.

You can open the paper in Codex's in-app browser and have GPT-5.5 read it with you and explain all the concepts.

This is the future. AI agents will be part of the target audience, and help us to understand anything we want.
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