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The Computomatix Times

All the posts fit to save — curated from @computomatix's bookmarks & likes on X
Science & Health4/10

Sinclair Says He Takes Low-Dose Daily Tadalafil for Brain Health

David Sinclair says he takes low-dose daily tadalafil for long-term organ health, particularly the brain, citing vascular dementia as a preventable cause of dementia. The post quotes a cardiologist thread on the drug's vascular benefits and a study suggesting it may slow cancer spread.

David Sinclair @davidasinclair · ·🔖 bookmarked
Original post · 1 min read
I take low-dose daily tadalafil for long-term organ health, especially the brain. Vascular dementia is the second most common and most preventable cause of dementia
Afshine Emrani MD FACC @afshineemrani
1/10 I'm a cardiologist. I've recommended low-dose daily tadalafil for years — not for the bedroom, but for the blood vessels.

Most people think of these as sex drugs. I think of them as vascular drugs that happen to work below the belt.

And a study published two weeks ago suggests they may do something nobody predicted: make it harder for cancer to spread.

Here's the complete picture — the mechanism, the evidence, who should consider them, who absolutely shouldn't, and what I actually do.
♥ 4.3K · ⟲ 260 · 👁 780.0KView on X ↗

More in Science & Health

Science & Health8/10

U.S. Government, Google and Meta Launch $1.8 Billion AI Biology Data Effort

U.S. Government, Google and Meta Launch $1.8 Billion AI Biology Data Effort▶

Molly O'Shea reports a $1.8 billion coalition including Biohub, the Department of Energy, NIH, Meta, Google DeepMind and Isomorphic Labs to build the largest open, AI-ready biological dataset to help models predict biology and treat disease.

Molly O’Shea @MollySOShea · ·♥ liked
Original post · 1 min read
BREAKING: The U.S. government, Google, Meta & Zuckerberg-backed @biohub are launching a $1.8B push to build the data layer for AI biology.

The goal is to create the largest open, AI-ready biological dataset ever assembled, giving models the data needed to better predict how biology works & ultimately help treat disease.

The coalition is massive:

› Biohub committed $500M
› DOE is investing $500M+ across measurement, modeling & compute
› NIH is bringing $500M+ of federally funded datasets & repositories
› Meta, Google DeepMind & @IsomorphicLabs are jointly investing another $300M

This is effectively an infrastructure buildout for AI biology.

Instead of just building bigger models, they’re attacking one of the biggest bottlenecks in biology AI today, generating standardized, high-quality biological data at massive scale & making it openly available to researchers.

$1.8B committed to turning biology into something AI can increasingly model, predict & engineer.
♥ 1.7K · ⟲ 255 · 👁 109.1KView on X ↗
Science & Health7/10

FDA Clears First Human Age-Reversal Trial From Life Biosciences

FDA Clears First Human Age-Reversal Trial From Life Biosciences▶

Vaibhav Sisinty reports the FDA cleared the first human age-reversal trial, citing animal research on partial reprogramming and Life Biosciences' $80 million raise to pursue it, though the post's claims about mouse and monkey results are not independently verified.

Vaibhav Sisinty @VaibhavSisinty · ·♥ liked
Original post · 1 min read
This is insane 🔥

The FDA cleared the first human age-reversal trial

A Harvard professor proved you can reverse aging by 75% in 6 weeks in mice cured blindness, reversed Alzheimer's, MS, ALS, kidney and liver disease then confirmed it works in monkeys

Now humans are next. Life Biosciences raised $80M to make it happen

His words "The eye is just the beginning. We believe we can treat every tissue. A whole body reset"
♥ 3.6K · ⟲ 607 · 👁 234.5KView on X ↗
Science & Health7/10

Evidence API Lets Users Search 100M Papers for Scientific Claims

Evidence API Lets Users Search 100M Papers for Scientific Claims▶

James Zou announces the Evidence API from Paperclip, which lets users search over 100 million papers to find evidence for and against a scientific claim in about a second. He cites coffee and diabetes risk as an example query.

James Zou @james_y_zou · ·♥ liked
Original post · 1 min read
What if,
for any scientific claim,
you can search 100M+ papers to find the strongest evidence for and against it
⚡️in 1 second?

That’s now possible with Evidence API! 🚀
paperclip.gxl.ai/evidence-api

For example, does drinking coffee reduce diabetes risk?
paperclip.gxl.aiPaperclipPaperclip — search, read, and analyze 11M+ biomedical papers, regulatory documents, clinical trials, and biological databases (UniProt, PDB, ChEMBL) from the co
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Science & Health6/10

Phone-Free Trial Shows Gains in Attention and Depression Symptoms

Noah Smith shares a post by Brandon Luu, MD, reporting that two weeks without phone internet improved sustained attention by an effect size comparable to about ten years of aging and reduced depression symptoms more than the average antidepressant effect.

Noah Smith 🐇🇺🇸🇺🇦🇹🇼 @Noahpinion · ·♥ liked
Original post · 1 min read
Putting down your phone is more effective than antidepressants
Brandon Luu, MD @BrandonLuuMD
After blocking phone internet for 2 weeks:

1) Sustained attention improved by an effect size comparable to ~10 years of aging

2) Depression symptoms improved more than the average antidepressant effect
♥ 1.4K · ⟲ 137 · 👁 94.9KView on X ↗
Science & Health6/10

Randomized Trial Finds Plain Water Gargling Cuts Respiratory Infections

Randomized Trial Finds Plain Water Gargling Cuts Respiratory Infections

Brandon Luu, MD, highlights a randomized trial in which gargling with plain water three times daily reduced upper respiratory infections by about 36%. He describes it as one of the cheapest cold-prevention interventions.

Brandon Luu, MD @BrandonLuuMD · ·♥ liked
Original post · 1 min read
One of the cheapest cold-prevention interventions I’ve seen:

Gargling with plain water 3x/day reduced upper respiratory infections by ~36% in a randomized trial.
♥ 4.9K · ⟲ 285 · 👁 521.5KView on X ↗
Science & Health7/10

Anduril and Palmer Luckey Win Wildfire XPRIZE for Rapid Fire Detection

Palmer Luckey says Anduril won the Wildfire XPRIZE for detecting and suppressing a wildfire within 10 minutes of ignition. He argues that even small gains could save the U.S. roughly $500 billion a year lost to wildfires.

Palmer Luckey @PalmerLuckey · ·♥ liked
Original post · 1 min read
Thanks, Peter! This is the beginning of the end for destructive wildfires. In a country that loses ~$500B every year to wildfires, even tiny gains make for huge savings, to say nothing of the incalculable value of lives and homes.
Peter H. Diamandis, MD @PeterDiamandis
Congrats to @PalmerLuckey and Anduril for winning the Wildfire XPRIZE - for detecting and suppressing a wildfire within 10 minutes of ignition!
♥ 25.1K · ⟲ 1.7K · 👁 836.4KView on X ↗