David Sinclair Questions Metformin's Anti-Aging Reputation
David Sinclair argues that metformin's anti-aging reputation rests mostly on evidence from people who already had diabetes. The post is a brief claim with no supporting data.
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David Sinclair argues that metformin's anti-aging reputation rests mostly on evidence from people who already had diabetes. The post is a brief claim with no supporting data.
Gergely Orosz argues Scrum made sense for teams shipping every two to three months but held back teams doing daily or continuous deployment, which startups and Big Tech abandoned a decade ago.
Klaas @forgebitzit's funny how scrum masters completely disappeared
and no one really cared
Sarvesh Shrivastava predicts that Grok Bot combined with Jev will make more businesses millionaires in 2026 than crypto did, and urges readers to paste a prompt into Grok Bot. The post quotes a promotional thread claiming a local SEO playbook can reach $100k per month.
Sarvesh Shrivastava @bloggersarveshIf I woke up bankrupt tomorrow, this is how I’d get to $100k/month with Grok Bot + SEO. — THIS IS THE PLAYBOOK I BUILT FOR MYSELF. not for clients. not for a course. for the day everything goes wrong.
Grok Bot + SEO. 90 days. $100k/month.
i've been doing local SEO for 14 years. i've used
Trackmind promotes a 17-page Stanford paper that it says sets out the Hidden Markov Model framework used by quant firms such as Jane Street and Two Sigma, released free. The post is an enthusiastic summary and quotes a separate thread on randomness and measurement.
Trackmind @0xTrackmindYou Were Taught to Fear Randomness and Called It Bad Luck. The Real Thing Can Be Calculated. — Randomness is not the enemy of understanding. It is the last thing most people ever learn to measure, and once you can measure it, it stops being frightening and starts being useful.
Almost everyone
cat.png shares a free MIT-licensed repository of notes from three SpaceX engineers who shipped a product in 72 hours using Grok Bot agents. The notes cover a chief-of-staff bot, scoped specialist bots, proof-before-merge rules, cost figures and 40 documented antipatterns. The quoted post describes a 14-page guide on a growth lead building bots to replace his own work.
unicode @unicodef1wnSpaceX AI's growth lead built a bot to replace himself. I turned his session into a 14-page PDF.
He started with six bots. One job each.
→ researcher, product marketer, website ops, performance, analyst
→ each one takes the handoff from the one before it
→ he leaves comments in the doc, the bot reads them and redrafts
Then he built the seventh bot.
It read the other six. It read every place he had to step in and fix them.
Then it ran three campaigns and told him nothing until they were done.
His words: "I don't want to talk to any of the other bots."
Also in the PDF:
→ 8 prompts, copie…
Interlap announces that SimSlim, an open-source project that disables unneeded background daemons so more iOS simulators can run on one Mac, has passed 2,000 GitHub stars. The developer thanks contributors and testers.
Navin Kabra comments that it is interesting to see what a designer does with Jev, quoting a post titled as a designer getting access to Jev. The post contains little detail.
Stefan @heystefan_when a designer gets access to Jev
DHH advises readers to drop a negative attitude and embrace optimism, calling it doctor's orders. He is responding to a quoted post linking repetitive negative thinking to buildup of Alzheimer's-related proteins in the brain.
Nicholas Fabiano, MD @NTFabianoRepetitive negative thinking is linked to Alzheimer’s protein buildup in the brain.
A short post from physician Aniruddha Malpani says weight loss can come with vision loss, accompanied by a photo. The post offers no details or sourcing.
Ansh Nanda shares AGENTS.md rules banning unit tests written after code and favoring end-to-end tests with verifiable artifacts. He responds to a quoted post about an AI agent generating trivial unit tests.
dex @dexhorthyleave it to your boy opus to add 10 unit tests to ensure a constant string contains various substrings
Taha Tesser reports that macOS 27 includes a new fm command-line tool that lets users run Apple's on-device Foundation Models from the terminal.
David Sinclair links to a article asking whether GLP-1 drugs are longevity drugs, citing a new Nature study reporting that semaglutide extended lifespan in preclinical experiments.
Paul Graham says he and Jessica have been watching Professor T and call it very good, suggesting it is a near substitute for more Sherlock Holmes stories from Conan Doyle.
SK comments on lawyer A.M. Singhvi entering the Tata Sons dispute as lead counsel, a development contrasted with Harish Salve's earlier role for the other side. The post quotes Singhvi's statement on shareholder rights.
Abhishek Singhvi @DrAMSinghviHaving worked closely with Ratan Tata earlier, being aware of his legacy and not only knowing personally all the principal actors on both sides in the current so called Tata dispute but also having deep, genuine and abiding respect for and excellent equations with all of them, my first reaction, as I enter the fray as the lead lawyer for one side, is one of sadness and regret that these issues could not be solved amicably. But in the ultimate analysis, fundamental rights of shareholder-owners cannot be nullified in the manner in which they have been. To stultify shareholder ownership rights …
Karthik shares a claim that Coimbatore has about 5,500 organised senior-living units, more than any other Indian city, and notes Bangalore was once called a pensioner's paradise.
Trading Warz claims selling S&P 500 puts changed his life, describing 186 trades and 1,500 contracts that expired worthless, and promotes a live Spaces session. The post makes unverified profit claims and reads as promotional.
Fastlane promotes Jev for Marketing, a tool that generates unlimited social media accounts and videos from a website URL to promote a product. The post is a short product pitch with a video.
Neend Ki Rani says actress Neha Sharma earns Rs 200,000 monthly by charging subscribers Rs 290 each, citing around 6,826 people. The post is a celebrity earnings claim with little sourcing.
A developer introduces laya-mlx, an open-source MLX port of the Laya typed decision model, claiming 7-14 ms decisions on an M3 Max and a demo playing Snake at 60 decisions per second. A GitHub repository is linked.
Ashlee Vance says it is hard to describe the effect Emergent Ventures is having on India, quoting Tyler Cowen's announcement of the 19th India cohort. The post links to a Marginal Revolution update.
tylercowen @tylercowenEmergent Ventures India, 19th cohort: marginalrevolution.com/marginalrevolution/2026…
Alex Fedotoff shares a board of 199 storytelling drama ads from Pocket FM, encouraging readers to model them for ecommerce products. The post quotes Rohan Nayak's claim that Pocket FM grew to $500M ARR while EBITDA profitable and outlines its growth tactics.
Rohan Nayak @RohanNayak2app.gethookd.aiPocket FM 4★+5★ Longest-Running (English) — GetHookd199 ads saved to this board on GetHookd.We grew from ~0 to $500M ARR, adding $250M last year alone while being EBITDA profitable.
1,300-word post on every growth tactic that worked for us:
1. What got us from 0-$400M ARR in the US works in every country.
2. Retention and Monetisation Hacks.
3. Localization > Translation.
4. Experiment with $1M internal seed checks.
5. Pivoting to only AI content production unlocked 100% ARR growth.
Pocket FM is like Netflix for audio-only dramas, with our own pool of one-person studios.
1. Acquisition Playbook for 0-$10M ARR in any country in 6 months
We run a 90 sec video trailer of an audio d…
Matthew Berman says the Jev tool scrolled 723 ads and scored them as 30 buyer personas at a cost of 22 cents, with availability planned through StealAds and MCP. A quoted post describes Jev breaking down 724 live ads from 37 brands in 40 seconds.
Matthew Berman @TheMattBermanjev is INSANE.
in 40 seconds it broke down 724 live ads from 37 brands.
every hook. every format. offer. cta. awareness stage. landing page mismatch. used 9 cents of tokens.
(will be avail in @stealads + mcp)
Dmitry Korzhov lists seven marketing workflows Jev can accelerate, including ad library scans, creative scoring, search term sorting, fatigue detection and lead scoring. He says it runs through the Ryze AI app and an MCP connector for under $3, and quotes Ira Bukht claiming SEO/GEO audit costs dropped 90%.
Ira Bodnar @irabukhtJev dropped the price of SEO/GEO fixes by 90%
Agents that audit and fix a client's SEO/GEO used to cost us ~$250
Here's where the savings come from:
1/ 30x faster reads of Search Console and PostHog/Mixpanel data
2/ 30x faster checks of what ChatGPT searches on Bing
3/ 30x faster modeling of what users ask Gemini and Claude
4/ 30x faster scans of who ChatGPT and Claude cite
5/ 30x faster analysis of the sources behind those citations
6/ 30x faster gap analysis: why they get cited and we don't
7/ 30x faster fixes across 1,000s of pages on large client sites
8/ 30x faster sorting of wh…
Codila describes a seven-step setup connecting the Jev decision layer with GrokBot on a local computer via a Typesafe API key and a usage router skill. The post promotes a GitHub repo and deep-dive article, and quotes a claim that Jev is the 'Internet moment' for AI agents.
codila @0xCodilaJev is the "Internet" moment for the AI industry
It tells your agents and LLMs what to do next, in milliseconds and at almost zero cost
If you set it up correctly, you will have the AI engineer’s stack for 2028
In this article, I show you how
Hiten Shah comments on the engineering effort behind Devin's Cloud Mac, which Cognition's Jake Kelley describes as rebuilt in Rust, and argues that verifying an agent's work will consume much of the stack. The quoted post covers disk, networking, provisioning, VNC and computer use.
Jon Kelley @jkelleyrtpSeveral months of work went into building Devin's Cloud Mac!
We had to rebuild its disk, networking, provisioning, VNC, and computer use from scratch, in Rust.
Read my first X article about how it all works 😊
Aaron Levie argues that personal agents like Muse will make tools and sites compete for agent attention, forming the biggest consumer tech shift since the App Store. A quoted post claims Meta launched an agent app store built on connectors and is positioned to profit from user data.
Ejaaz @cryptopunk7213zuck essentially launched a new app store for agents today and Meta’s perfectly placed to crush it, you’re looking at a multi-trillion dollar opp if they pull it off:
- instead of apps, agents get equipped with connectors i.e. plugins to any app, service or software tool.
- suddenly your agent goes from a useless chatbot to an action-oriented helper that gets shit done for you
but it gets even better - meta has collected ALL the data about you. they know what you want, when you want it which means they know exactly WHICH connectors to list in a marketplace and HOW MUCH to charge because the…
Chamath Palihapitiya praises a deep dive from his team on the open versus closed AI race. The quoted report says open-weight models have come within roughly four months of the best publicly evaluated closed frontier models.
Chamath Palihapitiya @chamathDeep Dive: The Open vs. Closed AI Race — Open-weight models have come within roughly four months of the best publicly evaluated closed frontier models, and the gap between them has only gotten more volatile.
That is turning the open vs.
Chamath Palihapitiya predicts that within 12 months the top three models will be open source, with American cloud providers such as Nebius, Iren, Baseten, Together and Fireworks capturing the economic gains. He quotes Guillermo Rauch reporting that open models held 78.4% of token volume on Vercel AI Gateway.
Guillermo Rauch @rauchgLooks like today may be a record day for token volume % of open models on Vercel AI Gateway:
🟦 Open 78.4% 🟨 Closed 21.6%
While spend 💲 usually tells a different story, #3 and #4 today are Moonshot AI & DeepSeek. Adding Z.ai, their combined spend surpasses OpenAI (#2).
(Do note that's the spend for inference of the model across providers (mostly in the US), not revenue going directly to the open weight labs.)
Sunil Pai shares that his blog post on the senior engineer death spiral is drawing heavy engagement and DMs. He says it describes a counterintuitive but effective solution and hopes managers will use it to support their reports.
sunil pai @threepointonenew post: the senior engineer death spiral
sunilpai.dev/posts/the-senior-engineer-death-s…
a friend just started a big job and asked for some advice. so I braindumped a monologue about a super common failure mode I see with engineers and posted it here, hope it helps whoever it can.
AI Search says Jev is closed and available only via API, and offers Nimble, a GitHub project from Bespoke Labs, as an open version that performs comparably. The post links to the Nimble repository.